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Its use has been discontinued in many countries because of its antinutrient properties, decreasing the absorption of various dietary metals (e.g., phosphorus, zinc, calcium, and copper) in the gastrointestinal tract (Bloot et al., 2023)

Treatment with Milk Thistle Extract (Silybum marianum), Ursodeoxycholic Acid, or Their Combination Attenuates Cholestatic Liver Injury in Rats: Role of the Hepatic Stem Cells

doi: 10.1182/blood.V100.10.3832 68 DulucqSLaverdireCSinnettDKrajinovicM

Koumenis, C

For example, ganoderic acid A activates the NRF2/SLC7A11/GPX4 axis (108), whereas saponins derived from Astragalus membranaceus act on the NOX4/NRF2 pathway to restore iron balance (109)

By targeting the underlying causes of pain, these therapies can provide significant relief and improve mobility