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Inhibiting the expression of iron response element binding protein 2 (IREB2), the main transcription factor of iron metabolism, can significantly increase the expression of FTL and FTH1, thereby inhibiting ferroptosis induced by erastin 28

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It has been demonstrated that the most common form of this enzyme, cytosolic isoform 2, can function as both an FAD synthase and a hydrolase

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Exp Neurol 323:113076

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Monge-Fuentes et al

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