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Differences in efficacy may be related to dose, fatty acid type (ALA, EPA, DHA), individual differences (e.g., FADS1/2 gene polymorphisms) ( 5.2 Autism spectrum disorder ASD mostly occurs in infants and young children after the age of 2 years, and is mostly manifested as social communication deficits and the existence of limited, repetitive behaviors or interests, which are improved by the commonly used drugs risperidone and aripiprazole, while ASD patients have a higher probability of suffering from depression, anxiety, sleep difficulties, epilepsy, and intellectual disability ( The above studies have shown that premature infants are more likely to develop ASD, so some studies have found that Omega-3 fatty acids supplementation during pregnancy can reduce the probability of ASD, and the use of more fish oil can effectively improve the occurrence of the disease ( 5.3 Tourette syndrome TS syndrome is a form of involuntary, repetitive, rapid motor or vocal tics that usually occur during the teenage years, and the exact cause is unknown ( 5.4 Epilepsy Epilepsy is a persistent neurological condition primarily characterized by periodic episodes of seizures (Table 3)

Viechtbauer, 2010), employing a random-effect model via the metafor R package ( 3 Results 3.1 Study selection and characteristics The search strategy identified 2,183 potential articles: 1,299 from PubMed, 353 from Scopus, 527 from Embase, 4 from manual screening