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Chao et al

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As a consequence, the invasion of gram negative enterobacteria initiate the inflammatory cascade wherein Toll like receptor-4 (TLR-4)-induced proinflammatory cytokine upsurge along with NLRP3 inflammosome activation attract the neutrophils eventually leading to oxidative burst, chronic inflammation, apoptosis and ultimately intestinal ulceration [140]
Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signalling pathways leading to induction of matrix metalloproteinases

In addition to genetic causes, habits and lifestyle have also been identified as being responsible for HHcy

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