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Moreover, the best results were obtained using anaerobiosis for the carnitine metabolism induction phase and aerobiosis for the biotransformation of crotonobetaine into L-carnitine [14]

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Central to this cascade is glutamate-induced hyperactivation of N -methyl- D -aspartate receptors (NMDA receptors), driving pathological calcium influx that overwhelms mitochondrial buffering capacity [103] (Fig

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