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PMCID: PMC10535703

Subsequently, we compared these results with the lipid peroxidation levels in the hippocampus and we observed a relationship between the oxidative damage and the deficit in the passive avoidance test (Graphic 2)

The replacement of Asp207 with Arg, which increases the positive charge, was expected to increase the membrane binding simultaneously with the FFL2 destabilization by removing its interaction with the -helix bundle