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A more in-depth analysis of the effect of oxygen levels permitted conditions to be optimized [63, 64] and showed that -butyrobetaine production was dramatically decreased when the biotransformation was performed under aerobic conditions as a consequence of the inhibition of crotonobetaine reductase by oxygen [14, 16, 63, 65]

From all the metabolites in our analysis TMAO was the top microbiota-derived compound that affected most strongly eGFR predictions (Supplementary Fig

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

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2021 Jun;14(6):e012293