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As a significant source of trimethylamine-N-oxide (TMAO), red meat negatively impacts both the gut microbiota and host health (Wang et al., 2019)

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Journal of Microscopy (2010)

Specifically, as an endogenous ligand of the aromatic hydrocarbon receptor, trans-3-indoleacrylic acid upregulates the expression of aldehyde dehydrogenase 1 family member A3, leading to increased production of NADH by utilizing retinol as a substrate

To understand CoQ10's role, we must look at the exact biochemistry of energy synthesis