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doi: 10.1016/j.jaad.2018.01.020

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As a result, the usable window can shorten when the seal is damaged, the solution is no longer clear, the storage range has not been followed, or the vial has been handled without consistent aseptic technique

These symptoms occur due to fluid shift and pressure on the nerves, which usually improve with dose adjustment or taking short breaks after consulting with your healthcare provider

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