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Maintaining protocol integrity across multi-week TB-500 studies requires more than just showing up at the same time daily

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An alternative approach that has been explored experimentally in the porcine ischemic injury model to limit formation of LA inhibitory fragments while maintaining the ability of LA to induce recovery of barrier function involves addition of small doses of LA over time and suggest that 0.1 M LA applied every 45 min is effective (49)

Recommended Frequency: Weekly or as needed

Of the 20 countries, 13 did not need EC review or approval
