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At the molecular level, TQ molecule induces cell cycle arrest by inhibiting the cyclin E and cyclin D activation while upregulating other cell cycle inhibitors such as p21 and p27, leading to G1-phase arrest

Biomimetic nanoerythrosome-coated Aptamer-DNA Tetrahedron/Maytansine conjugates: pH-Responsive and targeted cytotoxicity for HER2-Positive breast Cancer, Advanced materials (Deerfield Beach, Fla.), 34 (2022) e2109609

While TBI induction decreased the expression (0 fold) in rats in Group II

It is not approved for therapeutic use in humans, and no large-scale clinical trials have been conducted to evaluate its safety or efficacy as a medication

Meftahi et al., 2021)