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It is interesting that -CG challenge increased the Beclin-1 expression and the LC3II/LC3I ratio, indicating the enhancement of intestinal autophagy activity by -CG challenge

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External factors that contribute to the production of free radicals include smoking, environmental pollutants, radiation, drugs, pesticides, industrial solvents, and ozone (Gven et al

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Pooled findings from two randomized, placebo-controlled clinical trials indicated that supplementation with folic acid and vitamin B12 was linked to increased rates of colorectal cancer incidence because of aberrant DNA methylation [171,172]

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