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Vitamin B12 plays a vital role in various physiological processes, including energy production, metabolism, blood cell formation, and nerve function

Key functions of vitamin B12 include: Haematopoiesis supporting the production of healthy red blood cells and preventing megaloblastic anaemia Neurological function maintaining the myelin sheath that protects nerve fibres and supports cognitive function DNA synthesis facilitating cell division and growth throughout the body Metabolism working alongside folate to convert homocysteine to methionine, an amino acid important for protein synthesis Deficiency in vitamin B12 can lead to serious health consequences, including pernicious anaemia, peripheral neuropathy, cognitive impairment, and in severe cases, irreversible neurological damage

People with pernicious anemia or people who cannot absorb vitamin B 12 from their intestines will need injections of vitamin B 12 every one to three months indefinitely

DOI: Keywords: Vitamin B12 deficiency, pernicious anaemia, primary care, cyanocobalamin, hydroxocobalamin Abstract Background : Vitamin B12 deficiency is common in primary care but its treatment practices vary across centres

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