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Reduced expression or activity of GPX4 has been observed in fibrotic lung tissue, reducing its ability to detoxify lipid peroxides and rendering cells more vulnerable to ferroptosis (Tsubouchi et al., 2019)

Non-cleavable linkers despond on the monoclonal antibody degradation after ADCs internalization within the lysosomes and endosomes to generate the metabolites containing the active cytotoxic drugs with or without a portion of the linkers

The green utilisation lies under the scope of bionanotechnology and is a part of environmentally friendly, economical routes with a reduction in toxic byproducts