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Ferroportin 1 (FPN1), made by the SLC40A1 gene, is the only ferrous export protein found in mammals

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Hepcidin regulates intrarenal iron handling at the distal nephron

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Critically, this mechanism is selective for senescent cells because non-senescent cells do not accumulate FOXO4 in PML bodies and do not depend on FOXO4-p53 sequestration for survival
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