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Description
Mnn10 maintains pathogenicity in Candida albicans by extending alpha-1,6-Mannose backbone to evade host dectin-1 mediated antifungal immunity
Tolin et al
When serum B12 results are equivocal or clinical suspicion remains high despite normal B12 levels, additional tests may be requested: Methylmalonic acid (MMA) : Elevated levels indicate functional B12 deficiency at the cellular level, though availability may be limited in primary care and levels can be elevated in renal impairment Homocysteine : Also elevated in B12 deficiency, though less specific and also affected by renal function Intrinsic factor antibodies : To investigate pernicious anaemia, the most common cause of B12 deficiency in the UK Anti-parietal cell antibodies : May be tested if pernicious anaemia is suspected but intrinsic factor antibodies are negative Identifying the underlying cause is crucial for appropriate management
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Qiu YB, Wan BB, Liu G, Wu YX, Chen D, Lu MD, et al
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