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AfCycDesign: Cyclic offset to the relative positional encoding in AlphaFold2 enables accurate structure prediction, sequence redesign, and de novo hallucination of cyclic peptide monomers and binders.

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Biological activity assays revealed that MSNs-ss-SA exhibited superior efficacy in inducing resistance to rice sheath blight compared to conventional SA, which was primarily due to its ability to enhance physical barrier formation, strengthen antioxidant defense systems, upregulate the expression of key defense-related genes, and increase chitinase synthesis, collectively triggering both systemic acquired resistance and induced systemic resistance