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The optimization process was performed with the Adam optimizer, and the optimized parameters were as follows: best test loss= 0.12563762068748474, batch size= 4, and learning rate= 0.001

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NAR can upregulate the expression of miR-22, increase the expression of ZO-1, occludin, and claudin-1 proteins, and inhibit the expression of NLRP3 protein, and the application of miR-22 antagomir can reverse these changes

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