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111 , E4110E4118 (2014)

Homocysteine levels, which were elevated at baseline, and protein carbonyl groups (a marker of oxidative stress) decreased in a dose-dependent way, with a 37% reduction of homocysteine and a 23% reduction of protein carbonyl groups with 800 mg per day

Within the framework of the National Heart Lung and Blood Institute (NHLBI, NIH) Recipient Epidemiology and Donor Evaluation Study (REDS)-III RBC-Omics study, four blood centers across the United States enrolled ~13,800 healthy donor volunteers of different ages, sex and ethnicities

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The redox activity of the metals induces oxidative stress and impairs the nervous system (Sharma et al., 2014)