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A still unsolved issue, connected with the role of carnitine in modulating gene expression (Figure 1) is the link between mitochondria and nucleus: acetylcarnitine produced in mitochondria would reach the nucleus providing acetyl units (Figure 2)

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In addition to oral l-carnitine, etomoxir (5 mg/kg of body weight) was dissolved in 0.9% (w/v) NaCl and administered intraperitoneally once every three days for 4 weeks in the l-carnitine + Etomoxir group [19]