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Several in vitro studies described below have demonstrated acrolein-induced alterations in cellular mitogen activated protein kinases (MAPKs) which are likely to contribute to other mechanisms of toxicity

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Treatment with SGI-110, a second-generation DNA methyltransferase inhibitor (DNMTi), re-sensitizes OCSCs to platinum (140)

(Wang et al., 2021) identified miR-29b-3p and miR-378g as potential miRNAs upstream of NNMT by bioinformatics analysis

CNTF: ciliary neurotrophic factor) Melanocortin receptor signaling Recent evidence indicates the single-minded homologue 1 (SIM1) transcription factor acts as a proximal mediator for the anorectic, but not thermogenic, effects of melanocortins [67]