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This shift transforms microglia from having neuroprotective effects to exerting neurotoxic effects, ultimately causing neuronal injury and cognitive decline (22)

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Maestri M, Romigi A, Schirru A, Fabbrini M, Gori S, Bonuccelli U et al (2020) Excessive daytime sleepiness and fatigue in neurological disorders

Tumor necrosis factor (TNF) induces NFB and AP-1 nuclear-binding activities and both are required for normal expression of both GCL subunits and GS in rat

Paired helical filaments and straight filaments contribute to the formation of NFTs, a hallmark of neurodegenerative disease (Wang et al., 2021)

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