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Of these, 8 had a substantial drop in solubility around pH 7.0 and the lowest in vivo potency

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Thus, it has been pointed out that the brain is totally reliant on methionine synthase activity to remethylate homocysteine (19)

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In terms of future direction of investigation, we can continue to comprehensively evaluate the long-term safety and effectiveness of Rg1 through large-scale, multi-center clinical trials