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In in vivo and in vitro studies, melatonin was proven to increase the level of Nrf2 in cardiomyocytes exposed to oxidative stress

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Nies and Keppler (2007) present evidence that ABCC2 is the major transporter for the elimination of glutathione S -conjugate, glucuronic acid conjugate and sulfate conjugate of various toxins and carcinogens from hepatocytes into the bile, from kidney proximal tubule cells into urine, and from intestinal epithelial cells into the intestinal lumen

Journal of Cellular and Molecular Medicine

Benito JM, Lu H Shi Y, Jacamo RO, McQueen TJ, Konoplev S, Bueso-Ramos C, Zweidler-McKay P, Handisides D, Hart CP, Andreeff M , Konopleva M

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