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Nemecheck, P., et al

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In support of the role of betaine and choline in protecting against hepatocellular carcinoma, Lupu et al., [173] reported that, in a mouse model, the deletion of betaine-homocysteine methyltransferase gene, which is implicated in choline metabolism resulted in the spontaneous elevation of S-adenosylhomocysteine levels and development of preneoplastic foci in the liver

however, daily alcohol consumption results in the deterioration of both semen volume and sperm morphology [48]

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