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Mitochondria are also the main source of reactive oxygen species (ROS) and reactive nitrogen species (RNS)

2.2.2 Endoplasmic reticulum: regulator of lipid metabolism and redox homeostasis The ER maintains cellular homeostasis through protein synthesis, lipid metabolism, and calcium storage ( - localized to the ER membranemediates cystine import for GSH synthesis (66)

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