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Based on 77,690 independent reflections of better than 10 A resolution, a final R-factor of 18.6% was obtained with a model obeying standard geometry within 0.025 A in bond lengths and 2.4 degrees in bond angles

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All published research is preclinical in nature

Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor cells in the cuprizone murine model of Multiple Sclerosis

These fatty acids are converted into ketone bodies in the liver and, in severe cases, lead to diabetic ketoacidosis, a life-threatening emergency [80]