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Oxidative stress stimulates the activation of transcription factors and signaling pathways, partly through the activation of the innate immune response which turns on several cell signaling cascades that leads to release of cytokines and chemokines [73]

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L., Babior B

The switch from Th1 to Th2 is crucial for survival of the host, indicated by the findings that patients with severe hepatosplenic schistosomiasis have high levels of Th1-associated cytokines [Tumor necrosis factor (TNF), IFN], while asymptomatic patients exhibit high levels of Th2 associated cytokines (IL-4, IL-5, IL-13) and IgE (23)

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Indeed, COPD is mainly an inflammatory disease and different inflammatory pathways can be activated [18]