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While the chemical properties of the materials from which IOLs are made influences acute PCO rates, the no space, no cells principle also drives IOL design as PCO can only occur if residual lens cells can proliferate to numbers able to scatter light while migrating from their native location on the peripheral anterior lens capsule to the central posterior capsule (71, 72)

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In very simplified terms, one could say that methylation functions like an on/off switch in many contexts

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