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J Alzheimer's Dis 36, 197209

It also serves as a carrier of phosphate groups in phosphorylation reactions

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HSCs, the primary producers of ECM, play an indispensable role in the pathogenesis of liver fibrosis ( The pathogenesis of liver fibrosis is complex, with sustained HSC activation and ECM deposition due to chronic liver injury being major contributors ( in vitro and animal models has revealed multiple pathways by which glycyrrhizin inhibits HSC activation

Moreover, the p53 4KR98 mutant (R98/R117/R161/R162) failed to repress SLC7A11 transcription or induce ferroptosis [68], suggesting a critical role of p53 acetylation in SLC7A11-related ferroptosis

Unfortunately, the current therapies have limited efficacy, although sustained weight loss can alter the natural history of disease