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A 2008 review by Pickart in the Journal of Biomaterials Science summarized GHK-Cu's documented roles in wound healing, dermal remodeling, and skin elasticity, finding that the complex modulates both synthesis and degradation pathways in the extracellular matrix

It exists in a regulatory gray area as a research chemical, available for purchase for research purposes

It supports new collagen synthesis and slows its degradation

doi: 10.3389/fphar.2020.01021 187 TthGRothMWeckerleMSchreierP

doi: 10.1161/jaha.118.010606 169 YueC.YangX.LiJ.ChenX.ZhaoX.ChenY
Among the myriad regulators of these pathways, histone deacetylase 6 (HDAC6) emerges as a pivotal player due to its unique functions and substrates
