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Moreover, a variety of HDAC inhibitors are lack of specificity, thus, it is more critical to devote to developing effective and specific epigenetic targets against colorectal cancer and provide an optimized therapeutic regimen for CRC patients

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doi: 10.1016/j.biopha.2024.117297 266 EmaniLSRaoJKKumar DasappaJPecchioMLakey-BeitiaJRodriguezHet al

This distinction emerges at the MIE level, leading to distinct types of DNA damage, predominantly adducts from tobacco smoke and DSBs from radon-derived alpha particles (Figure 5), resulting in different mutation patterns

Conclusions Our observations with glutamate are consistent with the composite findings of 7 T MRS studies in schizophrenia and suggest that glutamate levels are lowered in ACC in both patients with early psychosis and those with longer-established illness