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In pediatric patients with sepsis, cytokines such as IL-1, IL-6 and sTNFR1, protease MMP8, chemokine MIP-1 and the alveolar epithelial marker SPD are potential biomarkers for persistent MODS

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coli mutants without CoQ 8 biosynthesis ( ubiA , ubiB , ubiE , ubiF , ubiH , ubiG ) or with a very low level of CoQ 8 ( 80%) in SMPs under oxidation of NADH or succinate in the presence of CIII inhibitors (e.g., antimycin A) or CIV inhibitors (e.g., potassium cyanide, KCN) (240)

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Based on the clinical-relevant effects by downregulation of CPT1A activity by genetic mutation (Fig