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According to UK product information, vitamin B12 has a good safety profile, particularly because it is water-soluble and excess amounts are readily eliminated by the kidneys

Nitric oxide synthase expression in hypertension induced by inhibition of glutathione synthase

doi: 10.1371/journal.pone.0209205 518 SuGLKoCWBercikPFalck-YtterYSultanSWeizmanAVet al

Therefore, it's unclear if the improvements were due to BPC 157 or simply the passage of time

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