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Urobilinogen is re-absorbed (about 10%) or broken down (90%) into urobilin and stercobilin (both of which are excreted in the feces)

While a constant exposure of quinone is not necessarily representative of an in vivo scenario, it is however, much more representative of an in vitro situation, whereby a constant source of quinone is essentially available in the extracellular media during cell culture 27

Molecular and Cellular Biochemistry 124 (2):149-158 Margarido TCS, Felicio AA, Rossa-Feres DC, Almeida EA (2013) Biochemical biomarkers in Scinax fuscovarius tadpoles exposed to a commercial formulation of the pesticide fipronil

doi: 10.3389/fcell.2025.1522873 Received 05 November 2024 Accepted 31 January 2025 Published 26 February 2025 Volume 13 - 2025 Edited by Jaime Villegas, Andres Bello University, Chile Reviewed by Maria Lambros, Western University of Health Sciences, United States Emanuel Jeldes, University of Edinburgh, United Kingdom Updates Copyright 2025 Rostami Ravari, Sadri, Mahdiabadi, Mohammadi, Ourang and Rezaei

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Activation of autophagy protects against acetaminophen-induced hepatotoxicity