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The role of TNF-alpha in human adipose tissue: prevention of weight gain at the expense of insulin resistance

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Significant targets and the effects of PKGI in SMC are activation of myosin light chain phosphatase, inhibition of PLC, inhibition of the IP 3 receptor, inhibition of plasma membrane localized L-type Ca 2+ channels, and activation of plasma membrane localized calcium-activated K + channels (commonly called the big potassium, BK, channels)

doi: 10.1126/science.1224631 89

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Moreover, certain varieties of free radicals generated during the stressed cellular function are generally responsible for activation of the adapter protein that regulates the signal transduction initiated via the TNF receptor, along with several IL receptors followed by the activation of TNF, TTRAP, and TRAFs [4,48]