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Description
These interactions result in metabolic stress, which can be toxicologically reflected in lack of drug efficacy or in a drug-related pathology

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In the lipid-rich liver environment, elevated CPT expression and FAO might increase mitochondrial ROS and lead to cell death of CD4 + T cells, thus promoting tumor formation in a murine model, which could be blocked by the CPT inhibitor perhexiline (Zhao et al

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Higueruelo, A., Schaeffner, B.C., Soler-Membrives, A., Dallares, S
