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The gut microbiome-joint connection: implications in osteoarthritis

doi: 10.1007/s12264-013-1330-2

Progesterone: Progesterone normally has calming, sleep-supportive effects on the brain and helps with sleep, so its decline can make it harder to fall and stay asleep, leading to less restorative sleep

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Dopamine naturally blocks prolactin release, so higher B6 levels create a dopamine-driven drop in prolactin

Mechanism of action: Although its exact mechanism of action is not yet fully understood, it is believed to affect neurotransmitters and neurochemical pathways in the brain that regulate sleep and stress