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As LTB4 is synthesized by 5-lipoxygenase, attempts have been made to inhibit this enzyme (e.g., GSK2190915, Zileuton) but have also failed because of side effects including hepatic toxicity [110]

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Perspectives on the Integration of Immuno-Oncology Biomarkers and Drugs in a Health Care Setting

Mller S, Gilberger TW, Krnajski Z, Lersen K, Meierjohann S, et al

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This innovative approach successfully distinguished healthy controls from clear cell renal cell carcinoma (ccRCC) patients in 176 urine exosome samples, achieving over 94% accuracy and significantly improving diagnostic capabilities for the disease