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Paralleling our increased understanding of the pathogenesis of DN, there must be refinements in our ability to measure quantitatively the different types of defects that occur in this disorder, so that appropriate therapies can be targeted to specific fiber types

Homozygous carnitine palmitoyltransferase 1a (liver isoform) deficiency is lethal in the mouse

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Furthermore, lactate induces monocyte differentiation into dendritic (DC) cells, which is associated with the suppression of mTORC1 activity [375]