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The different nature of these residues is suggested to be responsible for the differences in catalytic properties of mesophilic and extremophilic GGTs ( FIGURE 5 Recent crystallographic studies on L-Glu-bound BlGGT demonstrated that its active site channel constitutes two extensive pockets at the intersubunit interface lined mainly by hydrophobic residues

ACS Chem Biol 10:16041609 Zhang LL, Tang RJ, Yang YJ (2022) The underlying pathological mechanism of ferroptosis in the development of cardiovascular disease

Loss of SLC25A39 did not impact the levels of whole cell glutathione or most other mitochondrial metabolites but caused a specific 5-10 fold reduction in that of mitochondrial glutathione (Fig

There are other polymers-enabled delivery platforms that have been proved for successful brain-targeted delivery including semiconducting polymers, polysaccharides, gelatin and other synthetic or natural polymers

This review outlines the advantages and drawbacks associated with the use of -lipoic acid, as well as various nanotechnological approaches employed to enhance its therapeutic effectiveness, whether alone or in combination with other bioactive agents

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