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10.1093/ajcn/80.6.1611 [DOI] [PubMed] [Google Scholar] 17.James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH, et al

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The main lesion site in OA is concentrated in the articular cartilage region, and its early key pathological changes are highly correlated with cartilage degeneration

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13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig