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After binding to PLP, H241 rotated to the position adjacent to the PLP pyridine ring

This extended receptor activation is therapeutically important: it mimics the sustained reproductive hormone response needed to trigger follicular development

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Illustratively, epidermal growth factor (h-EGF) and transforming growth factor (h-TGF alpha), while stable in water, are rapidly degraded within minutes in gastric juice [58]

12 Moreover, much of the prior knowledge regarding HIF signaling has been generated from malignant tissue

pmid:13554481CrossRefPubMedGoogle Scholar Doets EL, Int Veld PH, Szczecinska A, et al