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Our findings that mitAspAT catalyzes a cysteine S -conjugate -lyase reaction with TFEC in vitro and is syncatalytically inactivated in the process (Cooper et al., 2002a) are consistent with the in vivo finding that this enzyme in the kidney is thioacylated after administration of TFEC to rats (Cooper et al., 2011)

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The western blot results indicated that OGD and erastin caused a decrease in SLC7A11 and GPX4 protein levels, which were rescued with the addition of Fer-1 (Fig