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In addition to supplying building blocks for GSH synthesis, GSH derived from astrocytes helps to support astrocyte regulation of the immune system

The mechanism involves nanoparticles targeting the BBB to either induce or inhibit P-gp, resulting in reduced P-gp expression

The regulation scales with delivery route and claimed therapeutic benefit

Exp Biol Med (Maywood) 228(8):891897 Koshinaka K, Toshinai K, Mohammad A, Noma K, Oshikawa M, Ueno H, Yamaguchi H, Nakazato M (2011) Therapeutic potential of ghrelin treatment for unloading-induced muscle atrophy in mice

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The dosage charts above assume monotherapy, using either retatrutide or tirzepatide alone