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10.3390/toxins14120818 81 Er-RouassiH.BakourM.TouzaniS.Vilas-BoasM.FalcoS.VidalC.et al (2023)

It does not restore immune health

[DOI] [PMC free article] [PubMed] [Google Scholar] 142.Kang JH, et al

The complexity of components and their varied solubility profiles across different solvents has driven the development of multiple extraction strategies [53], yet conventional methods often necessitate excessive solvent use, elevated temperatures, and extended processing times that risk degrading thermolabile compounds [51]

However, in AATD, the production of AAT polymer due to misfolding leads to the upregulation of pro-inflammatory cytokines such as CXCL1, CXCL2, TNF-, IL-1, IL-6, and IL-8, thereby promoting neutrophil recruitment (86, 87)

A central obstacle lies in their complex etiology: most cases result from polygenic contributions of multiple variants classified as benign, in interaction with multifactorial exposures across the lifespan