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Thus, elevated levels or activity of these mediators might provide an explanation for CD38 upregulation noted in SSc skin biopsies 24

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Again, the studies were small in size and heterogeneous, but the analysis showed that 95% of them reported a significant reduction of oxidative stress or DNA damage after treatments with antioxidants

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Finally, a growing body of work has recognized lipid peroxides as key mediators of many cellular diseases and even death, indicating that decreasing the production of lipid peroxides might be an effective strategy to improve the lethal effects of lipid peroxidation [7, 13]