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hypomagnesemia has been linked to an increase in endothelial permeability, decreased vasodilatation and an increase in the production of vasoconstrictor substances, and rapid damage to micro vessels, leading to focal hemorrhages and cerebral edema

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It is intended to be administered by intramuscular injection

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In the fully adjusted model ( Table 2 ) , IGF-1 serum concentrations were not associated with the risk of ALS neither in crude nor in fully adjusted models (top vs