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N Engl J Med 330(6):377381 Danese S (2007) Inflammation and the mucosal microcirculation in inflammatory bowel disease: the ebb and flow

Adjunctive modalities such as electrical stimulation and acupuncture may also provide benefit

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Five stages of evolving -cell dysfunction during progression to diabetes

5.3 Tryptophan metabolites Tryptophan metabolites are generated either through direct decomposition of tryptophan by gut microbiota (e.g., Clostridium, Escherichia coli ) into indole derivatives (such as IPA and indole-3-acetic acid (IAA)) or via host-cell-mediated processes (e.g., indoleamine 2,3-dioxygenase 1(IDO1)-catalyzed kynurenine production, 5-hydroxytryptamine (5-HT) synthesis by enterochromaffin cells) in coordination with microbial metabolism

PTEN regulates glutamine flux to pyrimidine synthesis and sensitivity to dihydroorotate dehydrogenase inhibition