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Subsequently, lipid peroxidation promoted the activation of IB kinase- (IKK)/NF-B, which further mediated chronic inflammation and impaired insulin signaling by inhibiting insulin-stimulated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB) activities (53)

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10.2147/JHC.S370255 [DOI] [PMC free article] [PubMed] [Google Scholar] Mo CK, Liu J, Chen S, Storrs E, Targino da Costa ALN, Houston A, Wendl MC, Jayasinghe RG, Iglesia MD, Ma C, et al

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10.1038/s41375-022-01634-w 21 HouH.QinX.LiG.CuiZ.ZhangJ.DongB.et al (2024)

This study also demonstrated that these receptors are functionally coupled to signal transduction mechanisms from early prenatal stages, highlighting their active involvement in early neurodevelopmental processes